HOP头外置体积描记系统

产品描述

      塔望科技开发的头外置式体积描记系统（Head-Out Plethysmography），采用特殊设计，使小动物的颈部与身体隔开，口鼻暴露在外面，实时测定容纳身体的腔室内气体容积与压力的变化。Glaab等对哮喘小鼠使用mACh激发后，取呼气中段流量(EF50 )下降55％时的mACh量( EF50)为指标来表示支气管反应的敏感性，研究证明，EF50和RL及CL有较好的相关性，可较好地反映呼吸系统的机械动力学改变。

产品特点  

       采用头外置式体积描记系统测量过程中，动物保持清醒状态，不需要麻醉，避免了创伤性气管切开术及麻醉的影响，使实验过程简便快捷，并适合长期跟踪研究。另外系统可扩展连接雾化给药器，对动物进行雾化给药，建立咳嗽、哮喘等呼吸道疾病模型，系统可检测和记录激发过程中呼吸常规指标和气道高反应的变化，用以评价支气管收缩情况。

不需要做手术，操作简单。

动物处于清醒状态，结果不受麻醉和手术影响。

可以实现在同一只动物上做长期跟踪实验。

配备气溶胶雾化模块 。（可根据实验要求选配）

可联合同步测量其它信号，如体温、血压、心电信号等。

可连接口鼻暴露系统，实时在线监测动物肺功能指标的变化。

检测参数

Ti：吸气时间（s）

Te：呼气时间（s）

PIF：最大吸气流速（ml/s）

PEF：最大呼气流速（ml/s）

Volbal：吸气时间/呼气时间

F：呼吸频率（次/min）

Vt：潮气量（ml）

Mv：分钟通气量（ml）

AV：累积体积（ml）

EF50：呼出50%气量时对应的呼气流速（ml/s）

EIP：吸气末暂停时间

EEP：呼气末暂停时间

TR：松弛时间

PenH：增强呼气间歇（enhanced pause）

Rpef：相对时间

应用领域

哮喘Asthma 

肺纤维化Lung Fibrosis

慢性阻塞性肺病COPD

急性呼吸系统疾病Acute Respiratory Disorders

模型开发Model Development 

安全评估 Safety Assessment

毒理学Toxicology

型号选择

用户名单

相关文献

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