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大动物全身体积描记系统(猴、兔子)

产品时间:2024-06-21 01:43:15

简要描述:

全身体积描记系统(猴、兔子)产品描述 无约束全身体积描记法(whole-bodyplethysmograph,WBP)可以对清醒自由活动的大动物进行肺功能及气道

详细介绍

全身体积描记系统(猴、兔子)


产品描述 

无约束全身体积描记法(whole-bodyplethysmograph,WBP)可以对清醒自由活动的大动物进行肺功能及气道反应相关的测试,避免了创伤性气管切开术及麻醉的影响,使实验过程简便快捷,并适合长期跟踪研究。

塔望科技开发的大动物全身体积描记系统,可用于猴的测量。测量时可直接将猴椅放入描记器内,通过软件可实时测量猴子的呼吸参数。


工作原理

该系统采用整体体积描记法(WBP),是一种肺力学相关的无创检查方法。实验室,将动物放进密闭的腔内,动物可以自由活动、进食、饮水。该方式操作容易且无需麻醉,呼吸接近自然,可以长时间的对多个动物进行同步检查。

 动物在描记器内呼吸时,胸腹呼吸会导致描记器产生相应气流变化,传感器描记相应的信号变化,并由计算机软件分析得到分钟通气量,呼吸频率,潮气量等值。

WBP 体积描记器具有不同的尺寸规格,以容纳不同种类的动物。体积描记器分为参考室和主体室。动物被放置在主体室内,参考室用于减少环境噪音的影响。

体积描记器内置呼吸流量描记仪(内装有细孔滤网,用以在测量体积描记器动物呼吸流量波形时提供阻尼),并可在堵塞住呼吸速度描记器后作为压力型描记器使用。

顶部中心位置设有雾化给药进口,可向描记器动物进行在线雾化给药。

描记器还提供其它不同的端口,可以用来外接保持描记器内氧气浓度维持在合适程度的偏流系统,或用来监测二氧化碳及药物气溶剂浓度等。

无约束的 WBP 体积描记器还可以加上一个导线用来监测肺及心血管数据, 但需要事先对动物进行外科手术来安装血压传感器。

大动物全身体积描记系统(猴、兔子).jpg

猴子体积描记器(可内置猴椅)

大动物全身体积描记系统(猴).jpg猴子体积描记器(可内置猴椅)2.jpg

兔子体积描记器

兔子体积描记器.jpg



产品特点

· 适用动物:猴、兔子

· 不需要做手术,操作简单

· 可在动物在自然状态下呼吸的研究以及长期跟踪实验,适合进行药物初筛

· 具有药物气溶胶雾化模块

· 具有自动标定功能

· 可选配测量心电、血压、体温、心率等指标,可与植入式遥测设备联合使用

· 具有分析软件,数据可保存至excel或txt格式


检测参数

参数

简写

单位

描述

呼吸频率

F

BPM

每分钟呼吸的次数

每分通气量

MV

ml

每分通气量是指每分钟进或出肺的气体总量

最大呼气流量

PEF

ml/s

最大呼气流量

最大吸气流量

PIF

ml/s

最大吸气流量

呼气时间

Te

s

呼气时间

吸气时间

Ti

s

吸气时间

呼吸比

Volbal

-

呼吸时间比

潮气量

VT

ml

平静呼吸时每次吸入或呼出的气量

呼气中期流速

EF50

ml/s

呼出50%气量时对应的呼气流速

呼气末期暂停

EEP

s

呼气末期暂停时间

吸气末期暂停

EIP

s

吸气末期暂停时间

增强呼气间歇

Penh

-

(enhanced pause)用于量化支气管收缩程度的指标

松弛时间

TR

s

松弛时间

相对时间

Rpef

%

呼气开始到达到呼气峰值流量所占用的时间占整个呼气时间的比例

图片5.jpg


液体药物雾化器

液体药物雾化器.jpg

1.采用高频震荡微孔技术,雾化效率高

2.可通过移液枪微量加药

3.可以实现在线给药,给药的量和速度可以调节



数据采集与分析软件

数据采集与分析软件.jpg




适用领域

各种呼吸疾病研究,如:哮喘、肺纤维化、肺损伤、ARDS、肺癌等

安全药理:药物对呼吸系统的影响

睡眠呼吸:监测动物低通气、阻塞性呼吸暂停等

环境毒理:环境污染物对动物呼吸的影响

吸入式毒理:染毒物质对呼吸系统的毒性影响

高原医学:高原环境对呼吸系统的影响

其它需要对呼吸参数评价的场合


型号说明


名称

型号

说明

单位

大动物全身体积描记系统

WBP-P

适用于猕猴、食蟹猴

大动物全身体积描记系统

WBP-T

适用于兔子


用户名单


上海市中心医院瑞金医院复旦大学附属华山医院上海药物所
中国药科大学江苏珂玛麒生物科技有限公司重庆医科大学中国人民解放军总医院
北京中医药大学中科院城市环境研究所南京大学四川大学华西医院
苏州大学药明康德南京医科大学空军军医大学
兰州大学陆军特色医学中心大坪医院海军特色医学中心......



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