WBP全身体积描记系统（大鼠、小鼠）

无约束全身体积描记法（whole-body    plethysmograph，WBP）可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试，避免了创伤性气管切开术及麻醉的影响，使实验过程简便快捷，并适合长期跟踪研究。

实验时，将动物置于密闭体描箱内，体描箱与通向体描箱外的感应器连接。动物呼吸时，其胸廓的起伏使体描箱内容积发生改变，此容积变化通过压力换能器和放大器转换为电信号，经计算机处理后，其呼吸曲线显示于电脑屏幕上，图形经软件处理，可计算出潮气量（PEF）、呼气峰流速（TV）、呼吸频率等呼吸参数。

系统可扩展连接雾化给药器，对体描箱内动物进行雾化给药，建立咳嗽、哮喘等呼吸道疾病模型，WBP系统可检测和记录激发过程中呼吸常规指标和气道高反应的变化,用以评价,支气管收缩等。

产品特点

不需要做手术，操作简单

操作简单，可在动物在最自然状态下呼吸的研究以及长期跟 踪实验，适合进行药物初筛

具有气溶胶雾化模块

最多同时监测64只动物

具有自动标定功能

具有饮水瓶和食物口，可进行长期连续监测

适用于小鼠、大鼠或其它动物

具有多种功能升级选项，适用不同研究，如低氧干预、脑电 监测、呼吸代谢监控等

雾化给药:精确、定量

检测参数

呼吸频率

潮气量

呼吸流量

每分通气量

吸气时间

呼气时间

吸气流量峰值

呼气流量峰值

吸气末暂停

呼气末暂停

松弛时间

Penh 

累积体积

其它参数

相关扩展应用

吸入式毒理	低氧研究	呼吸代谢监控、嗅觉行为学
将染毒物质引入动物体积描记器,用于毒理研究	可用于低氧或高氧实验	监测吸氧浓度、CO2浓度、呼吸代谢率 可以用于嗅觉刺激相关的行为学实验
光遗传/EEG/电生理集成	活动跑轮监测联用	持续注射给药、微透析联用
可以和光遗传技术、EEG、 EMG、电生理等技术联用	同步监测动物活动量 可增加呼吸代谢监控功能	可实现清醒状态下连续给药、采血、微透析实验
同步视频监测	咳嗽检测	各种动物呼吸检测
同步的视频录像文件	通过软件自动监测咳嗽事件	可定制各种大动物体积描记器，如兔、犬、猴等

其它生理指标测量

可在麻醉或清醒状态下测量心电、血压、体温、心率等指标，可与植入式遥测设备联合使用；如果您有特殊的实验需求，请联系我们具体商谈。

WBP与脑电肌电监测联用

同步监测EEG和EMG波形图、呼吸信号等，可用于监测动物睡眠状态

Novel whole body plethysmography system for the continuous characterization of sleep and breathing in a mouse A. B. Hernandez, J. P. Kirkness, etc., J Appl Physiol 112: 671–680, 2012

可选配的功能模块：

· 同步视频监测：同步的视频录像文件

· 咳嗽检测：通过软件自动监测咳嗽事件

· 其它生理指标测量：可在麻醉或清醒状态下测量心电、血压、体温、心率等指标，可与植入式遥测设备联合使用

检测参数

Ti：吸气时间（s）

Te：呼气时间（s）

PIF：最大吸气流速（ml/s）

PEF：最大呼气流速（ml/s）

Volbal：吸气时间/呼气时间

F：呼吸频率（次/min）

Vt：潮气量（ml）

Mv：分钟通气量（ml）

AV：累积体积（ml）

EF50：呼出50%气量时对应的呼气流速（ml/s）

EIP：吸气末暂停时间

EEP：呼气末暂停时间

TR：松弛时间

PenH：增强呼气间歇（enhanced pause）

Rpef：相对时间

适用领域

· 各种呼吸疾病研究，如：哮喘、肺纤维化、肺损伤、ARDS、肺癌等

· 安全药理：药物对呼吸系统的影响

· 睡眠呼吸：监测动物低通气、阻塞性呼吸暂停等

· 环境毒理：环境污染物对动物呼吸的影响

· 吸入式毒理：染毒物质对呼吸系统的毒性影响

· 高原医学：高原环境对呼吸系统的影响

· 其它需要对呼吸参数评价的场合

型号选择

*可以根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请来电咨询。

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